‘may’ is my most despised headline word. This article sounds like they may be onto something in mice trials anyway.
This will certainly work 100% of the time, and with no awful consequences.
Remember that Alli pill a few years back that blocked fat absorption and gave everyone diarrhea?
No, but that’s essentially what Wegovy/Ozempic does. I’m pretty sure diarrhea is necessary for weight loss (it’s not).
Nah, ozempic and Co change sugar absorption and satiation. People on it primarily eat way less instantly, apparently they just feel full and don’t feel any desire to keep going. It also slows sugar absorption which is why it helps manage diabetes, so that might also play some role
So far we’ve found it thickens the intestinal lining and significantly messes with the reward pathways, we’re not sure what the long term effects could be. It seems like at best, you basically have to stay on it indefinitely or regain the weight (which is true of current weight loss drugs)
It certainly does mess with reward pathways, seems to counteract my antidepressant and Adderall.
And yeah, I’m aware of the regain weight fun. My insurance currently has a lifetime cap of the benefit. So that will be interesting to see how that plays out. My hope is that the habits I’m forming stick, but I have doubts about that.
Does the thickening of the intestinal wall contribute to the weird bowl changes? Seems like it either moves extremely fast or takes a week, no in between
As for the thickening of the bowel, I have no idea, but it seems like the bowel movement speed and that are both side effects
And as for making it stick - here’s my take. Animals don’t become obese… Except when you feed them highly processed food. There’s also a theory floating around that seed oils drive sugar cravings, and the fat they release does the same thing
So my advice would be this - use this opportunity to fix this. If you burn the old fat, get rid of your sugar cravings, and eat better food you might be able to fix your system in a way people mostly only do by moving to somewhere with better food culture for years
Avoid processed food and seed oils as much as possible. Take advantage of the time you have on it, and stack the deck in your favor while you can
Processed food is simple enough to identify just because there is so much of it. I’m not familiar with seed oils so I’ll look that up.
But yeah. The sugar cravings are the hardest part of everything. The Wegovy thankfully limits how much I can consume, but it’s still there.
Seed oils are like canola, soy, “vegetable”, sunflower, etc. They’re the cheapest, so they’re used wherever they can be
As for alternatives, some people say grass fed butter/ghi is the easy to go, personally I mostly use olive oil (although I’m not super clear on why that’s different)
Ultimately, something is very wrong with our diets, and seed oils + sugar are where the experts offering explanations seem to be pointing. There’s other things it could be, like micro plastics and the million other containments in our food and water allowed in doses that don’t cause obvious harm, and even foods like tomatoes and potatoes that contain toxins (ones that are minimal if you prepare them properly, but we don’t prepare them how we used to)
I definitely recommend researching it, and I’d be interested to hear what you come up with
I have no doubt ads for ‘ozempic/watevgy class action lawsuits’ are in our future. anytime I see a drug take off like that I assume the side effects will be interesting.
Alli block fat absorption, I don’t think the two you mentioned do.
One of your breasts will grow by 3 inches in diameter. The other gets a much larger and more sensitive second nipple towards the very top of your chest at the base of your neck completely visible regardless of how conservative you dress like.
The drug name is ofcourse, “Niplovyadalimumaboxidazeoicbenzoplastaze” it’s fairly simple to draw.
Oh, it’s fine, the brain is a different kind of fat! /s
I think it’s called exercise. I’ve seen a meme about exercise. Do not recommend
People hurt themselves that way. Play it safe, walk slowly to the fridge and back.
On it!
I always feel insulted when I go to the fridge for a snack and my smart watch says “nice job staying active”
We should be able to respond with varying degrees of enthisiasm: Thank you! Alright then. Hmph Meh Eff off.
You know… For sentiment analysis.
Kinda reminds me of dinitrophenol (DNP), another miracle weight loss pill that converted stored calories to heat.
Works great up until it literally cooks you to death.
This new method of converting white fat to brown fat to heat sounds like it’s in that same neighborhood.
If it works, cool! But be cautious if you see a bottle of some shit claiming to do this at your local pharmacy.
Wasn’t the issue with dinitrophenol not so much the self-cooking effect but it had a really small window of working dose vs toxic dose? So even if you didn’t die of hyperthermia you’d die of it’s various carcinogenic, mutagenic or other incompatibilities with cells?
Not really if you look into the literature. There were several studies done at Stanford and several hundred thousand people that took it for fat loss and less than 100 deaths from what I’ve seen. Also, a majority of those deaths were from suicide, which is both a sad thing and a terrible way to go. The deadly dose was about 5-6x the normal dose. There was a case of a girl ODing on it to get ready for spring break and I believe she was around 10x the standard dose. Note dosage is based off body weight.
Now there are other issues that can occur because of the MoA it causes you to burn through zinc and magnesium. There are thyroid issues that can occur, as well as the possibility of cataractics. Then there’s the proton slip and electron leakage within the mitochondria. This is what causes a majority of the problems as it’s a positive feedback loop for negative cascades. That can be almost entirely negated by keeping dose lower and doing your cardio. It can be done safely if you know what you’re doing but most people aren’t that reasonable.
Someone wrote an interesting book on it and took more of a conspiracy standpoint on it claiming it could be effective fat loss but because it was cheap and easy it would cut into big pharma making money. Can’t say I agree with everything in the book but there was some useful information.
There’s also a newer compound called BAM-15. In research it’s more effective at fat loss and can be taken at much higher doses safely. I believe they got up to 20x the dnp standard dose without negative side effects in the lab rats.
Tl;dr take your medicines at the prescribed dosages, and consult with a licensed physician before making changes to medical regimens.
coming at a time when temps are going up, permanently (well, for any human lifespan) people eating too much then burning calories to dump as waste heat completely tracks.
I take stims everyday and it’s hell in summer
I’ve been wondering for a while if burned fat releases protein as if you had eaten the fat
Okay, how do I get my hands on some of the stuff they used so I can inject it into my abdomen?
Oily rectal discharge anyone?
… exercise? :-P
Never!
Diet
As the other reply mentioned, “Never!” :-D
Scientists have figured out a ton of things in a lab setting. But most of that is not something that scales up to the real world.
I like the mix of seriousness (serious scientific topic) and sensationalism (fat cells burning calories) in this article.
That sounds dangerous, the whole purpose of fat is to store energy if you’re smoking your own supply you won’t have anything left to sell.
