Initially, THC boosted brain metabolism and synaptic protein levels, indicative of heightened cognitive processes. Subsequently, it shifted towards reducing metabolic activities in the body akin to the effects seen with caloric restriction or intensive exercise, known for their anti-aging benefits.
Idk, I’m high right now and my memory is shit.
Bro is doing PI work on the horny account.
What? Maybe your app is broken, those links are the same.
Or is it?
Younger brains have fewer memories. This checks out.
Short term vs long term
That’s what they mean by reversing brain aging
The publication itself, which seems to be legit, and well done.
Haven’t had a chance to read all of it, but it isn’t badly executed by a quick scan.
I am glad you linked that, because the article and site itself did not inspire confidence
Why wouldn’t you look for the study itself in ANY article like this? It’s literally linked 1/3 of the way down the actual article.
The very opening basically repeating the name of the college twice and the stocks at the top had me immediately back out of the article as it came across as effectively trash. I then looked at the comments here and was surprised there was an actual publication linked
Part of the reason our world is in the shit it is right now is people like you more focused on appearances than content. And the worst part is you don’t even consider it a personal failing.
Reading your comments as I scroll: maybe you added some insight; but your delivery is crass. It makes you seem deliberately elitist… and makes me ignore your “angry” comments. You’ve made the conversation worse by adding to it, without consideration of anything besides your own opinion
And the worst part is you don’t even consider it a personal failing.
Isn’t that ironic.
our delivery is crass. I
I don’t care?
You’ve made the conversation worse by adding to i
The opposite in fact, I pointed out the intellectually dishonest tactic of the thought terminating cliche and then made reference to the actual study, which apparently all of you who ‘read the article’ seemed to miss the link to, and are kind of salty that I did not.
g besides your own opinion
5 decades of experience dealing with average people has proven to me that rarely has my opinion been the less functional one. Yes I am arrogant, and I don’t really care much about the opinions of others because most people never really bother giving any serious thought to anything they repeat or insist and I’m tired of the time and effort I do take to deepen my understanding of these topics is casually dismissed.
Have you ever sat down and thought about how a dollar flows through the economy from printing to disposal? I have and it took hours across several days, and I’m STILL SURE I missed some aspects of counterfeiting and outsider art but I can bet you a box of donuts that almost no one in this thread has even spent more than 120 minutes in their lives considering it unless it is part of their degree or career. Not even hedge fund managers know the whole picture.
Or how about figuring out the square acreage of space farm you would need to feed and oxygenate a single human? Because I have and it’s 17 - 22 acres depending on how many legumes you can stand in your diet for your average human. I don’t even think the Muskrat has broken down the circular crop rotation cycle well enough to keep their soil fertile for 3 harvests and he STILL thinks he’s going to get to Mars in his lifetime.
That’s the other thing that pisses me off, there are a fucktonne of idiots with bad ideas that fail constantly making a hell of a lot more money than the people who predicted those failures and were promptly ignored.
It’s like a Cassandra complex but instead of having meaningful prophecy ignored, it’s a clear eyed vision of our current present reality that gains the most scorn and vitriol. It kind of makes me hate all of humanity until proven otherwise on an individual basis.
If you buy a gift for someone, but they refuse to accept it, who then owns the gift? You do!
Your anger doesn’t upset me, but you’re still the one left holding it and experiencing it
You sound smart enough to figure out how to find some therapy, my friend. You should try and do that for yourself, or work harder at self-control and compassion
Don’t bother typing a long-winded response, I’m moving on. Good luck to you in all of your endeavors!
Maybe I’m misreading the only plot that mentions dosing numbers anywhere. It looks like the largest dosing group is getting 3mg/kg/day. That’s a lot scaled up to a 100kg person (like 10x a normal gummy for example).
It was three different doses, 0.3, 1, and 3 mg/kg per day
It was also delivered via subcutaneous pump, which is usually done with a mind towards a gradual dosing rather than a single push of the total amount all at once.
The kind of pump listed in the article previously linked was an osmotic pump.
Here’s an excerpt from a different paper describing the various methods for substance delivery:
Osmotic pumps are internally implanted devices that use an osmotic displacement system to infuse a preloaded substance into an animal. Use of these pumps permits constant dosing without the need to handle an animal after the initial implant surgery. Extracellular fluid is absorbed at a constant rate by an osmotic salt layer immediately beneath the permeable outer membrane. As the osmotic layer absorbs fluid, it swells and puts pressure on an impermeable reservoir in the center of the pump. The reservoir then expels the loaded substance from the pump at a constant rate through a flow moderator. The outflow can pass directly into the tissue surrounding the pump, or a cannula can be attached to the pump to direct the flow into a blood vessel or specific tissue.
Osmotic pumps are cylindrical in shape and come in sizes small enough for mice. These devices are surgically implanted either subcutaneously or intraperitoneally. The flow rate is fixed, and the duration of action varies from 3 d to 6 wk, depending on the size of the pump and the delivery rate selected. Pumps cannot be refilled but can be implanted sequentially to prolong dosing.
I’m not up on the dosing levels in humans, So I I don’t have the ability to know offhand if 3mg/kg spread over the day is unusually high (pun partially intended) or not. There’s a section I can’t find easily (I’m actually dyslexic so it takes me a while to get through this kind of dense and complicated writing) where they mentioned having a higher dose as a point of comparison.
Thanks this is a lot of great detail on the dosing mechanism that I think is really interesting. I love reading up on the experimental details and the actually components used to make these experiments work.
300mg of orally ingested THC spread out over 24 hours is about equivalent to consuming 1 typical candy/gummy every hour for 24 hours of the day. A reasonable or average or normal person would be uncomfortably high at these dosages. I also imagine the bioavailability of oral ingestion is less than the dosing mechanism you described although I’m not sure (is that getting taken up through the lymphatic system? How does it differ from oral ingestion or injection into the bloodstream?).
Fascinating stuff, thanks for sharing your knowledge.
deleted by creator
I voted for this because I want it to be true. Yay, science!
never really expected so many prohibitionist shitbags on lemmy. Off to the blocklist you and your ilk go!
Same energy as “wine is good for you!” As it turns out, no. Wine is absolutely poisonous to you.
I like hearing this so it must be true
It can also be true independent of one’s liking it.
That little aphorism you just trotted out is a thought terminating cliche, something that contributes nothing and artificially ends discussion.
You chose it deliberately to denigrate the study with zero evidence, and 11 people agreed with you.
Disturbing for lemmy.
There was an implied /s there.
And now there’s an explicit block here, free for you.
You don’t get to ‘it’s just a prank bro’ someone else’s stupidity.
I wonder if micro dosing can give the same effects? I am a control freak and don’t like to be high but worry about cognitive decline. Especially since I got long covid and fucked up my olfactory system. Brain damage sucks.
@karashta
Hell Yes!
Best news I heard all week, and there’s been some good stuff.
#MedicalCannabisThat’s why I’m so smrt
I believe it. A generation of leaded gas people that smoke have good life advice.
